Neurotensinergic periaqueductal gray‐rostral ventromedial medulla‐spinal dorsal horn pathway
نویسندگان
چکیده
منابع مشابه
Morphological evidence for a neurotensinergic periaqueductal gray-rostral ventromedial medulla-spinal dorsal horn descending pathway in rat
Neurotensin (NT) is an endogenous neuropeptide that exerts potent opioid-independent analgesic effects, most likely via the type 2 NT receptor (NTR2). Previous morphological and electrophysiological studies suggested that the NT-NTR2 system is primarily localized in structures that constitute the descending pain control pathway, such as the periaqueductal gray (PAG), the rostral ventromedial me...
متن کاملBlockade of GABAA receptors in the midbrain periaqueductal gray abolishes nociceptive spinal dorsal horn neuronal activity.
Single spinal dorsal horn neuronal responses to noxious skin heating or innocuous skin brushing were recorded in pentobarbital anesthetized rats. The heat-evoked activity was selectively abolished by blockade of GABAA receptors in the midbrain periaqueductal grey (PAG) by microinjections of 40 or 400 pmol bicuculline. It is concluded that antinociceptive output neurons in the PAG that trigger d...
متن کاملCardiovascular Effect of Dorsal Periaqueductal Gray During Lipopolysaccharide-induced Hypotension
Introduction: The central mechanism related to the cardiovascular response to lipopolysaccharide (LPS)-induced hypotension is not entirely known, but it is suggested that numerous brain areas such as dorsal periaqueductal gray (dPAG) are involved in this process. In the current work, the cardiovascular effect of the dPAG during LPS-induced hypotension is investigated. Methods: The study animal...
متن کاملDorsal periaqueductal gray-amygdala pathway conveys both innate and learned fear responses in rats.
The periaqueductal gray (PAG) and amygdala are known to be important for defensive responses, and many contemporary fear-conditioning models present the PAG as downstream of the amygdala, directing the appropriate behavior (i.e., freezing or fleeing). However, empirical studies of this circuitry are inconsistent and warrant further examination. Hence, the present study investigated the function...
متن کاملPostnatal maturation of endogenous opioid systems within the periaqueductal grey and spinal dorsal horn of the rat
Significant opioid-dependent changes occur during the fourth postnatal week in supraspinal sites (rostroventral medulla [RVM], periaqueductal grey [PAG]) that are involved in the descending control of spinal excitability via the dorsal horn (DH). Here we report developmentally regulated changes in the opioidergic signalling within the PAG and DH, which further increase our understanding of pain...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2013
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.27.1_supplement.535.6